Neurometabolic Imaging Lab

Adaptive Baseline Fitting (ABfit)

Fri, 29 May 2020 00:00:00 +0000

Very pleased to announce the acceptance of my new MR Spectroscopy analysis method “Adaptive Baseline Fitting” (ABfit), currently in press at Magnetic Resonance in Medicine: link to preprint. A badly structured MRS analysis software ramble follows.

In my opinion, MRS fitting algorithms haven’t improved in a significant way since the LCModel method was published, a staggering 27 years ago, and this has been both a blessing and a curse for MRS. A blessing because we’ve had access to a robust and highly optimised method for an long time, and it has rightly become the standard approach in the literature. A curse because the method is proprietary, relatively costly ($20k), and crucially, key algorithmic details are missing from the original paper - or terse to the point of obfustication.

Contact

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The Neurometabolic Imaging Lab is based at the Centre for Human Brain Health, School of Psychology, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.

E-mail : m.p.wilson@bham.ac.uk

BlueSky : martinw3141.bsky.social

Office : CHBH rm 224

Travel

Taxi: Edgbaston Park Hotel, 53 Edgbaston Park Road, B15 2RS.

Car: North East Car Park, 52 Pritchatts Rd, Birmingham B15 2SA.

Train: 10 min walk from University station.

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Educational articles

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Introduction to Magnetic Resonance Spectroscopy

Introduction to Magnetic Resonance Spectroscopy

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Magnetic Resonance Imaging (MRI) scanners generate and measure water signals in our body to produce incredibly detailed pictures of brain structure, and are commonly used in hospitals to diagnose brain injury or disease. The same MRI scanning technology may also be used to perform a technique called Magnetic Resonance Spectroscopy (MRS) - which allows the levels of a number of brain metabolites (neurometabolites) to be measured. In MRS scans, a spectrum is typically obtained from a single brain region (Single Voxel Spectroscopy) which is subsequently decomposed into its constituent metabolite signals using advanced software analysis algorithms:

People

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Principal Investigator

Martin Wilson, PhD

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Publications

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Google Scholar

ORCID

Software, Code and Data

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Neurometabolic Imaging Lab

Adaptive Baseline Fitting (ABfit)

Contact

Travel

Educational articles

Introduction to Magnetic Resonance Spectroscopy

People

Principal Investigator

Publications

Software, Code and Data

Software developed by the lab

Primary github repository

SPectroscopy ANalysis Tools (spant)

TARQUIN

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